Pliaglis® Cream is the first and only FDA-approved topical anesthetic that combines the highest concentrations of two powerful ingredients, lidocaine and tetracaine, for fast onset and lasting effect.1

Self-occluding, Pliaglis® (lidocaine and tetracaine) Cream 7% / 7% has a proven safety profile and works in as little as 20 minutes for fast onset and lasting effect.2

  • 20 to 30 minutes for most procedures, and up to 60 minutes
    for more potentially painful procedures.2

Important Safety Information:

Indication: PLIAGLIS® (lidocaine and tetracaine) Cream 7% / 7% is indicated for use on intact skin in adults to provide topical local analgesia for superficial dermatological procedures such as dermal filler injection, pulsed dye laser therapy, facial laser resurfacing, and laser‐assisted tattoo removal. Contraindications: PLIAGLIS® Cream is contraindicated in patients with a known history of sensitivity to lidocaine or tetracaine, or local anesthetics of the amide or ester type and is also contraindicated in patients with sensitivity to para‐aminobenzoic acid (PABA) or any component of the product. Adverse Events: In clinical studies, the most common local reactions were erythema (47%), skin discoloration (16%), and edema (14%). The most common systemic adverse events were headache, vomiting, dizziness, and fever, all of which occurred with a frequency of <1%. Warnings/Precautions: Methemoglobinemia has been associated with use of local anesthetics such as tetracaine. PLIAGLIS® Cream should be used with caution in patients with severe hepatic disease. When using PLIAGLIS® Cream in conjunction with other local anesthetic agents, the total dose of anesthetic should be considered due to the potential for additive systemic toxic effects. Contact with the eyes should be avoided.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

References: 1. Electronic Orange Book. http://www.accessdata.fda.gov/scripts/cder/ob/default.cfm. Accessed September 10, 2012 2. Alster TS. The Lidocaine/Tetracaine Peel: A Novel Topical Anesthetic for Dermatologic Procedures in Adult Patients. Dermatol Surg 2007;33:1073–1081